Anti-DNA-PK Antibody

Generated in rabbit against the catalytic core of human DNA-PK, this polyclonal antibody from Antibodies.com is validated for western blot, immunohistochemistry, and immunofluorescence applications on cell lysates, frozen sections, and formalin-fixed paraffin-embedded tissue. DNA-PK is the central kinase of the non-homologous end joining pathway, where it phosphorylates downstream effectors during double-strand break repair and V(D)J recombination in developing lymphocytes, making this reagent relevant to DNA damage response research, genotoxic stress studies, and investigations of lymphoid receptor diversification. Supplied as 100 µl of unconjugated reagent in a single vial, the antibody supports multiple staining rounds; for handling, refrigerate upon arrival, protect from light, aliquot before freezing, and limit freeze-thaw cycles to preserve activity. The polyclonal format delivers broader epitope coverage than monoclonal alternatives, increasing the likelihood of signal retention across denatured lysates and cross-linked tissue preparations.