Anti-DNA ligase 3 Antibody

DNA ligase 3 is a critical enzyme in the DNA repair machinery, catalyzing the formation of phosphodiester bonds at single-strand breaks and participating in base excision repair, alternative end joining, and mitochondrial DNA maintenance. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against human DNA ligase 3 and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows, making it useful for probing ligase expression in fixed tissue sections, cultured cells, and lysed protein samples. Researchers investigating non-homologous end joining, nucleotide excision repair pathways, or mitochondrial genome stability in cancer and neurodegeneration models will find this reagent relevant to their work. The antibody is supplied in a 100 µL vial as a liquid preparation and should be stored frozen at -20 °C in single-use aliquots to limit freeze-thaw cycles and preserve binding activity over time. Suitable for research use only, this polyclonal reagent offers broader epitope coverage than monoclonal alternatives, increasing the likelihood of detecting the target across splice variants and post-translational modifications that may be present in different sample types.