Anti-DMP1 Antibody

Rabbit Polyclonal Antibody Targeting Dentin Matrix Protein 1

This unconjugated rabbit polyclonal reagent binds Dentin Matrix Protein 1 (DMP1), an extracellular matrix protein central to phosphate homeostasis and osteocyte function in mineralizing tissues. DMP1 regulates FGF23 production and hydroxyapatite deposition in bone and teeth, and loss-of-function mutations in the gene are associated with autosomal recessive hypophosphatemia, a heritable form of rickets. Researchers studying osteocyte biology, tooth development, and skeletal mineralization rely on anti-DMP1 antibodies to localize and quantify the protein across multiple model systems.

Supplied by Antibodies.com as a 100 µl vial at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the antibody is ready to use in Western blot and immunohistochemistry (IHC) workflows. Cross-reactivity has been validated against human, mouse, and rat samples, enabling consistent comparison between clinical specimens and rodent disease models. The unconjugated format allows pairing with any fluorophore- or enzyme-labeled secondary antibody, supporting fluorescence microscopy, chromogenic staining, and chemiluminescent detection on the same primary reagent.

Common applications include Western blot detection of DMP1 in bone or dental pulp lysates and IHC localization in decalcified tissue sections. The glycerol-stabilized formulation tolerates standard refrigerated storage and repeated freeze-thaw cycles, while sodium azide prevents microbial contamination during long-term bench use. Researchers probing mineralization pathways and phosphate-handling disorders frequently combine this polyclonal reagent with osteocalcin, FGF23, and MEPE antibodies to map the broader mineral-regulating network in tissue samples.