Anti-DMP1 Antibody

Dentin matrix protein 1 (DMP1) sits at the intersection of skeletal mineralization and phosphate handling, and this unconjugated rabbit polyclonal IgG reagent from Antibodies.com is built to detect the endogenous protein in human and mouse samples by western blot. Affinity-purified from rabbit antiserum and supplied as a 100 µl liquid vial aliquot, the antibody supports detection of DMP1 in osteoblast, osteocyte, and odontoblast lysates prepared from bone and tooth. Loss-of-function mutations in DMP1 cause autosomal recessive hypophosphatemic rickets (ARHR), where elevated FGF23 disturbs phosphate homeostasis and produces skeletal defects, making reliable detection valuable for studies of mineralized tissue and renal phosphate handling. The polyclonal format captures multiple epitopes across the protein, supporting recognition of both the full-length precursor and the C-terminal fragment generated by proteolytic processing in the extracellular matrix of mineralized tissue. The reagent is paired with standard HRP- or fluorescence-conjugated secondary antibodies for chemiluminescent or fluorescent readouts on PVDF or nitrocellulose membranes. For best results, store at -20°C and protect from repeated freeze-thaw cycles to preserve lot-to-lot activity.