Anti-DLX3 Antibody

Raised in rabbit against the distal-less homeobox 3 (DLX3) transcription factor, this polyclonal antibody from Antibodies.com supports research in developmental biology and cancer biology. DLX3 is essential for craniofacial, dental, and skeletal morphogenesis, and variants in the DLX3 gene underlie tricho-dento-osseous syndrome, a condition that disrupts the normal development of hair follicles, teeth, and bone. Recent studies have also implicated DLX3 in breast carcinoma progression, head and neck squamous cell cancer, and the regulation of epidermal differentiation pathways.

Provided as 100 µl of unconjugated reagent in a single vial, the antibody is validated for Western blot (WB) and immunohistochemistry (IHC) applications. It reacts with human and mouse samples, supporting comparative work between murine disease models and human tissue specimens. Typical uses include probing DLX3 expression in whole-cell lysates during osteoblast or keratinocyte differentiation assays, and localizing the protein in paraffin-embedded sections from tooth, bone, or skin tissues.

The polyclonal format recognizes multiple epitopes across DLX3, which can help when probing splice variants or mutant proteins. Store refrigerated and protect from light to avoid repeated freeze-thaw cycles and maintain activity. For research use only.