Anti-DLST Antibody

The polyclonal reagent from Antibodies.com targets human dihydrolipoamide S-succinyltransferase (DLST), the E2 core subunit of the mitochondrial 2-oxoglutarate dehydrogenase complex that catalyzes succinyl group transfer to coenzyme A during the TCA cycle. Produced in rabbit and supplied unconjugated at 100 µl per vial, the antibody has been validated for Western blot, immunohistochemistry, and immunofluorescence workflows.

DLST is encoded on chromosome 14q24.3 and localizes to the mitochondrial matrix, where it supports carbon flux through the citric acid cycle and contributes to NADH production. Investigators working on paraganglioma-associated variants, mitochondrial metabolism, and TCA-cycle enzymology use this reagent to monitor native protein levels, map subcellular distribution in fixed cells, and probe expression across human tissues. The unconjugated format gives flexibility in secondary antibody choice and supports custom labeling strategies for immunofluorescence imaging and chromogenic detection in IHC.