Anti-Dkk-1 Antibody

The polyclonal reagent raised in rabbit targets Dickkopf-1 (Dkk-1), a secreted Wnt signaling antagonist implicated in bone remodeling and tumor biology. Distributed by Antibodies.com as a primary antibody, this unconjugated preparation is supplied in a 100 µl vial and validated for Western blot and ELISA workflows across human, mouse, and rat samples. Investigators studying osteoblast differentiation, multiple myeloma-associated osteolytic lesions, or Wnt pathway modulation rely on Dkk-1 detection to characterize cross-talk between cancer cells and the bone microenvironment. The polyclonal format offers broader epitope coverage than monoclonal alternatives, useful when probing native or denatured Dkk-1 from conditioned media or cell lysates. For storage, refrigerate upon arrival and aliquot into working volumes to limit freeze-thaw cycles over the product shelf life. Suitable for in vitro research use only, the antibody integrates into panels examining β-catenin-dependent transcription, sclerostin interactions, and myeloma cell-line signaling studies.