Anti-DISC1 Antibody

Raised in rabbit against the Disrupted in Schizophrenia 1 (DISC1) protein, this polyclonal IgG antibody from Antibodies.com is supplied as 50 µl of unconjugated reagent validated for Western blot (WB) and immunohistochemistry (IHC) applications on human, mouse, and rat samples. DISC1 is a multifunctional scaffold protein highly expressed in the developing and adult brain, where it regulates neuronal proliferation, migration, axon guidance, and synaptic signaling through interactions with partners including PDE4B, NudE/NudEL, ATF4/5, and LIS1. Aberrant DISC1 function is a leading model for studying schizophrenia susceptibility, major mental illness, and neurodevelopmental disruption, making this reagent useful for probing endogenous protein levels, subcellular localization in fixed tissue sections, and signaling complexes in neural cell models. The polyclonal format broadens epitope coverage for detection of full-length and isoform variants, and the unconjugated format allows flexible pairing with user-selected secondary reagents and detection chemistries.