Anti-DIAPH1 Antibody

Raised in rabbit against the formin-family protein DIAPH1 (Diaphanous Related Formin 1), this unconjugated polyclonal antibody recognizes a cytoskeletal regulator that nucleates and elongates actin filaments at the barbed end, driving remodeling during cytokinesis, cell migration, vesicle trafficking, and filopodia formation. Supplied by Antibodies.com as a 50 µl vial of ready-to-use reagent, the antibody is validated for western blot and immunohistochemistry workflows on human, mouse, and rat samples, supporting studies of cytoskeletal dynamics, DFNA1-linked auditory defects, platelet cytoskeleton organization, and the Rho-GTPase signaling axis that governs actin assembly. The polyclonal format offers broad epitope coverage for tracking full-length DIAPH1 and its isoform variants in tissue sections and cell lysates, while the unconjugated chemistry leaves labeling open to a secondary antibody of choice or to custom fluorophore conjugation for immunofluorescence and other detection methods. For handling, store at -20 °C and divide into smaller aliquots to limit freeze-thaw cycles and preserve binding activity across repeated experiments. From Antibodies.com, this primary antibody is intended for research use only and fits laboratories investigating formin-mediated actin regulation, mechanotransduction, hearing-loss biology, and related cell-signaling pathways.