Anti-DIAPH1 Antibody

DIAPH1 (Diaphanous Related Formin 1, also called mDia1 or DRF1) nucleates and elongates linear actin filaments, coordinates stress fiber assembly, microtubule stabilization, vesicle trafficking, cytokinesis, and cell migration in non-muscle cells. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com supports Western blot and immunofluorescence detection of DIAPH1 on human and mouse samples.

Researchers apply it to studies of formin-mediated cytoskeletal remodeling, focal adhesion turnover, RhoA GTPase signaling, mitotic spindle positioning, and the contribution of DIAPH1 variants to autosomal dominant non-syndromic hearing loss (DFNA1). The polyclonal format provides broader epitope coverage than a monoclonal reagent, useful when probing post-translationally modified or alternatively spliced formin species.

Format: 100 µl vial of liquid polyclonal antiserum, IgG isotype, unconjugated for flexible pairing with anti-rabbit secondary antibodies. Shipped refrigerated for short-term stability; store aliquots at -20 °C, avoid repeated freeze-thaw cycles, and protect from light to preserve binding activity across long-term use.

Host species is rabbit, supporting clean detection on cultured mammalian cells, primary fibroblasts, and tissue sections derived from human or mouse tissue. Recommended for research use only applications in cell biology, neuroscience, and auditory research laboratories.