Anti-DGCR8 Antibody

DGCR8 (DiGeorge Syndrome Critical Region Gene 8) acts as an essential cofactor within the nuclear Microprocessor complex, partnering with the ribonuclease III enzyme Drosha to cleave primary microRNA transcripts into precursor miRNAs. This unconjugated recombinant rabbit monoclonal reagent from Antibodies.com is raised against the human DGCR8 protein and has been validated for Western blot and immunocytochemistry/immunofluorescence workflows, with confirmed reactivity on human, mouse, and rat samples. Supplied at 100 µl per vial in a buffer of TBS (pH 7.4) with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative, the antibody should be aliquoted for longer-term storage at -20 °C, handled briefly at 4 °C, and protected from repeated freeze-thaw cycles. Researchers studying microRNA biogenesis, the 22q11.2 deletion region, DiGeorge syndrome models, neural crest and cardiac developmental biology, and nuclear RNA processing pathways routinely use this clone to probe endogenous DGCR8 expression, complex assembly, and subcellular localization.