Anti-DGCR8 Antibody

This polyclonal antibody targets DGCR8 (DiGeorge Syndrome Critical Region 8), a nuclear RNA-binding protein that partners with the Drosha RNase III enzyme to form the Microprocessor complex responsible for the first cleavage step in microRNA biogenesis. Supplied as 50 µl of unconjugated rabbit IgG, the reagent cross-reacts with human, mouse, and rat samples, supporting studies of pri-miRNA processing, stem-cell self-renewal, and 22q11.2 deletion syndrome models. Validated applications include Western blot, immunohistochemistry on fixed tissue, immunofluorescence for subcellular localization, immunoprecipitation of endogenous DGCR8 complexes, and flow cytometry. The polyclonal format enables recognition of multiple epitopes across the protein, useful when probing post-translational modifications or characterizing patient-derived variants. Researchers in RNA interference, miRNA-mediated gene silencing, and DiGeorge pathobiology rely on Antibodies.com reagents for reproducible antibody-based detection. Store refrigerated to preserve activity; consult the supplied data sheet for working dilutions and matched secondary reagents for each application.