Anti-DFNA5 Antibody

DFNA5, also known as Gasdermin E (GSDME), is a pore-forming protein implicated in autosomal dominant non-syndromic hearing loss and in inflammatory pyroptotic cell death. This rabbit polyclonal primary antibody from Antibodies.com is raised against the human DFNA5 target and is supplied unconjugated for use in Western blot (WB) and Immunohistochemistry (IHC) workflows.

Provided as a 100 µL vial at 1 mg/mL in PBS containing 0.1% sodium azide and 50% glycerol, the reagent is ready for direct dilution into standard assay buffers. The polyclonal format offers recognition of multiple epitopes on DFNA5/GSDME, including cleavage fragments generated during gasdermin-mediated pore formation, which is useful for researchers tracking pyroptosis in cancer biology and immune signaling studies alongside auditory genetics investigations.

Reactivity is confirmed for human samples, and the 50% glycerol formulation supports standard frozen storage with minimal freeze-thaw degradation across long-term projects.