Anti-DFNA5 Antibody

Raised in rabbit against DFNA5 (also known as Gasdermin E / GSDME), this polyclonal primary antibody from Antibodies.com is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotectant. The unconjugated reagent is provided in a 100 µl volume and has been validated for Western blot detection of the human, mouse, and rat target. DFNA5/GSDME was first identified through autosomal dominant non-syndromic hearing loss research and is now recognized for its role in caspase-3-mediated pyroptosis, where cleavage produces an N-terminal pore-forming fragment that permeabilizes the plasma membrane. The reagent supports studies of inner ear hair cell biology, gasdermin family function, tumor suppression pathways, and the molecular switch between apoptosis and secondary necrosis in cancer cell death. Aliquot on receipt and store at -20 °C, avoiding repeated freeze-thaw cycles to preserve activity; the sodium azide component acts as a microbial preservative for working dilutions.