Anti-Desmin Antibody

This recombinant rabbit monoclonal antibody targets desmin, a type III intermediate filament protein that anchors the contractile apparatus in cardiac, skeletal, and smooth muscle cells. Produced by Antibodies.com as an unconjugated primary antibody, the reagent is supplied as a 100 µl vial in 1×TBS (pH 7.4) with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative. Validated applications include western blot, immunocytochemistry and immunofluorescence, immunohistochemistry, and flow cytometry, giving laboratories a single reagent that supports multiple experimental readouts in muscle biology and tumor pathology research.

Desmin is a widely cited marker for myogenic lineage and is routinely used to characterize rhabdomyosarcoma, leiomyosarcoma, and other neoplasms of muscle origin. Confirmed reactivity against human, mouse, rat, and zebrafish samples makes the antibody useful for cross-species studies ranging from cell culture models to whole-organism investigations of zebrafish myogenesis. To preserve activity, users should aliquot the stock upon arrival and minimize freeze-thaw cycles, diluting into appropriate buffers for immunostaining or blotting protocols.