Anti-Desmin Antibody

Desmin is a 53 kDa class III intermediate filament protein that forms the cytoskeletal scaffolding of cardiac, skeletal, and smooth muscle, where it links adjacent Z-discs and maintains structural integrity during contraction. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against desmin and binds the target in human, mouse, and rat samples, making it a useful tool for muscle biology research and for identifying cells of myogenic origin in tumor pathology. It is supplied as 100 µl of a 1 mg/ml stock in PBS containing 0.1% sodium azide and 50% glycerol, which protects the antibody during repeated freeze-thaw handling. Western blot and immunohistochemistry are the validated application areas, supporting clear visualization of desmin-positive fibers in tissue sections and the expected band in lysates. Because desmin expression is retained in rhabdomyosarcomas, leiomyomas, and leiomyosarcomas, the reagent is also used in differential diagnosis to distinguish muscle-derived tumors from non-muscle mimics. Researchers commonly pair this antibody with myogenin, MyoD, or smooth muscle actin to characterize myogenic differentiation in developmental studies and in disease models of desminopathy and cardiomyopathy.