Anti-DES Antibody [Assigned #A10837]

Desmin is a type III intermediate filament protein encoded by the DES gene and expressed in skeletal, cardiac, and smooth muscle, where it links Z-discs and intercalated discs to maintain contractile unit architecture. This unconjugated rabbit monoclonal IgG antibody from Antibodies.com targets desmin and is supplied as a 50 µL vial for use in western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

Pathology and cell biology laboratories rely on desmin as a myogenic lineage marker to distinguish rhabdomyosarcoma, leiomyosarcoma, and other spindle cell tumors of muscle origin from non-muscle mimics, and to characterize desmin-related myopathy in patient biopsies. In developmental studies, the antibody tracks commitment of mesenchymal precursors toward striated muscle and helps resolve cardiac remodeling in murine injury models, while in cell culture it supports verification of myogenic differentiation during induced pluripotent stem cell differentiation protocols.

The reagent is provided unconjugated, allowing direct conjugation to fluorophores, HRP, or biotin for custom detection assays. It is compatible with both paraffin-embedded tissue sections and cultured cell preparations, and the IgG isotype works with standard anti-rabbit secondary reagents and routine antigen retrieval on formalin-fixed specimens. Pair this probe with complementary markers such as vimentin, α-actinin, or myogenin to discriminate myogenic differentiation states in heterogeneous tumor panels and to map cytoskeletal organization during muscle development.