Anti-DENR Antibody

Raised in rabbit against the human Density-Regulated Protein (DENR), this unconjugated polyclonal reagent from Antibodies.com is intended for researchers studying translation reinitiation, ribosome recycling, and the non-canonical roles of the DENR–MCTS1 complex in protein synthesis. The antibody binds the native DENR target on Western blot and supports immunohistochemistry workflows on formalin-fixed tissue sections, with reactivity confirmed against human samples. Supplied as 100 µl of antiserum in a single vial, it is suited to standard immunoblotting at typical working dilutions and to chromogenic IHC detection without a secondary reporter already attached. DENR is widely investigated in the context of cell growth control, stress responses, and oncogenic signaling, where altered reinitiation has been linked to proliferative phenotypes, making well-characterized polyclonal tools useful for expression profiling across cell lines and patient-derived material. The polyclonal format increases the likelihood of recognizing multiple epitopes on the DENR protein, which can be advantageous when probing truncated isoforms, post-translational modifications, or samples where single-epitope monoclonal reagents give weak signal. Researchers comparing DENR expression between normal and transformed tissue, or tracking its redistribution under translational stress, can pair this reagent with appropriate HRP- or biotin-conjugated secondary antibodies for signal development. Storage at 2 to 8 degrees C is recommended for short-term use, with aliquoting advised if the antibody will be consumed over many weeks to limit freeze-thaw cycling and preserve lot-to-lot consistency across repeated experiments.