Anti-DEFB4 Antibody

This unconjugated rabbit polyclonal primary antibody from Antibodies.com targets human Defensin Beta 4 (DEFB4A / BD-4), a cationic antimicrobial peptide secreted by epithelial cells as part of the innate immune response to bacterial and fungal challenge. DEFB4 expression is widely studied in mucosal immunity, skin barrier biology, and inflammatory conditions including psoriasis and inflammatory bowel disease, where its levels are markedly upregulated.

Validated for Western blot and immunohistochemistry on human samples, the reagent is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, and is packaged as a 100 µl vial. The glycerol-supplemented formulation supports storage at -20 degrees C and protects activity through repeated freeze-thaw cycles. The polyclonal format recognizes multiple epitopes on the mature ~7 kDa peptide, supporting robust signal in IHC tissue sections and Western blot detection of endogenous DEFB4 in cell lysates.

Typical research applications include mapping DEFB4 expression across inflamed and healthy human epithelia, characterizing host defense pathways, and investigating antimicrobial peptide signaling in vitro.