Anti-DEDD Antibody

Affinity-purified rabbit polyclonal reagent targeting DEDD (Death Effector Domain-containing protein), supplied as a 100 µl liquid aliquot for research use only. This unconjugated IgG preparation from Antibodies.com is raised against a synthetic peptide corresponding to a region of human DEDD (UniProt accession O75618) and detects endogenous levels of the target in human, mouse, and rat samples. The antibody supports western blot analysis of whole-cell lysates and immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, making it useful for apoptosis and oncology research programs. DEDD contains a death effector domain shared by adaptors, regulators, and executors of the programmed cell death pathway; upon CD95-mediated stimulation the protein translocates from cytoplasm to nucleus, co-localizes with UBTF in nucleoli-like structures, activates caspase-6, and inhibits RNA polymerase I-dependent transcription. Confirmed cross-reactivity across human, mouse, and rat species (Q9Z1L3 and Q9Z2K0 orthologues) enables comparative studies in matched cell-line and tissue models. The unconjugated format allows flexible pairing with HRP, fluorophore, or biotinylated secondary reagents chosen by the end user. Store refrigerated upon receipt and aliquot to limit repeated freeze-thaw cycles.