Anti-DDX3X Antibody

DDX3X is an ATP-dependent RNA helicase encoded on the X chromosome that participates in translation initiation, ribosome biogenesis, stress granule assembly, and innate immune signaling. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com detects a protein of approximately 73 kDa and has been validated for western blot, immunofluorescence, and immunohistochemistry on human, mouse, rat, and monkey samples. Investigators apply this antibody to study DDX3X involvement in WNT signaling, viral replication, and oncogenic pathways including medulloblastoma and head-and-neck cancer, as well as DDX3X-linked neurodevelopmental syndromes in pediatric cohorts. The liquid formulation is supplied at 100 µl per vial and should be stored refrigerated to preserve activity through repeated freeze-thaw cycles; aliquoting upon first thaw is recommended for long-term studies. The polyclonal format provides recognition of multiple epitopes across the helicase, supporting detection in whole-cell lysates, fixed tissue sections, and cultured cell monolayers prepared for research use only.