Anti-DDB1 Antibody

The DDB1 protein (Damage-Specific DNA Binding Protein 1) is a critical component of the UV-damaged DNA-binding complex and serves as an adaptor for CUL4-based E3 ubiquitin ligases. This unconjugated Rabbit polyclonal antibody from Antibodies.com enables detection of DDB1 across Human, Mouse, and Rat samples using Western blot and Immunohistochemistry applications. Supplied as 100 µl of ready-to-use reagent, the antibody targets endogenous DDB1 for studies in DNA damage response, nucleotide excision repair, and ubiquitin-mediated protein degradation pathways. Research applications include profiling of CRL4 complex assembly, UV-induced DNA damage signaling, and investigation of viral hijacking mechanisms where pathogens exploit DDB1-containing ligases. The polyclonal format provides broader epitope recognition for reliable detection in whole-cell lysates and tissue sections. Suitable for chromatin biology, DNA repair mechanism studies, and characterization of Cullin-RING ligase substrates in cell biology research.