Anti-DcR1 Antibody

The DcR1 (Decoy Receptor 1) protein, also known as TRAIL-R3 or TNFRSF10C, is a glycosylphosphatidylinositol-anchored member of the TNF receptor superfamily that binds TRAIL but lacks a functional cytoplasmic death domain, so it cannot transmit apoptotic signals itself. This rabbit polyclonal antibody from Antibodies.com is raised against human DcR1 and validated for western blot (WB) and ELISA workflows, supplied as an unconjugated reagent in a 100 µL volume that supports multiple experiments.

Investigators studying TRAIL-mediated apoptosis regulation, tumor immune evasion, and resistance to death receptor signaling use anti-DcR1 antibodies to profile decoy receptor expression and dissect the balance between pro-apoptotic TRAIL receptors (DR4, DR5) and decoy receptors (DcR1, DcR2) on the cell surface. Each lot is affinity purified and provided without fluorophore or enzyme conjugation, allowing flexibility for custom labeling or direct application in immunoblotting and immunoassay protocols.

For handling, store the antibody frozen at -20 °C in working aliquots to limit freeze-thaw cycles and preserve reagent activity, and thaw on ice immediately before use. The polyclonal format offers broad epitope coverage for recognizing full-length human DcR1, which is of particular interest in cancer research where overexpression of this decoy receptor has been linked to escape from TRAIL-induced cell death.