Anti-DCN Antibody

The antibody detects Decorin, a small leucine-rich extracellular matrix proteoglycan that regulates collagen fibrillogenesis and modulates growth factor activity through binding partners such as transforming growth factor beta. Supplied by Antibodies.com as 100 µl of a 1 mg/ml stock in PBS with 0.1% sodium azide and 50% glycerol, this unconjugated Rabbit polyclonal reagent was raised against human Decorin and cross-reacts with mouse and rat orthologs, enabling comparative work across the most commonly used mammalian model systems.

Validated for western blotting, immunohistochemistry on fixed tissue sections, and immunofluorescence imaging, the polyclonal format offers multiple epitope specificities. This is helpful when assessing Decorin across tissues in which proteoglycan processing varies, including developing dermis, healing wounds, fibrotic lesions, and tumor stroma. Decorin's role as an endogenous TGF-β antagonist, its regulation of collagen fibril spacing, and its expression by fibroblasts and myofibroblasts make this reagent a practical tool for research in fibrosis, scar biology, tendinopathy, and stromal remodeling in cancer.

For storage, keep the vial refrigerated at 4°C for routine use; the 50% glycerol cryoprotectant also permits -20°C storage for longer-term holding, with freeze-thaw cycles limited to preserve antibody activity.