Anti-DBH Antibody

Rabbit polyclonal antiserum raised against dopamine β-hydroxylase (DBH), the copper-dependent oxidoreductase that converts dopamine to norepinephrine inside secretory vesicles of catecholaminergic neurons and adrenal chromaffin cells. The unconjugated reagent is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged as a 100 µl vial for routine immunoblotting workflows.

Antibodies.com validates this polyclonal reagent for Western blot on lysates of human, mouse and rat origin, supporting studies of sympathetic nervous system markers, adrenal medulla differentiation, and norepinephrine biosynthesis pathways. Laboratories investigating Parkinson's disease models, stress-axis signaling, or peripheral sympathetic activity rely on anti-DBH labelling to identify noradrenergic cell populations and chromaffin tissue in brainstem sections and adrenal preparations.

Polyclonal reactivity broadens tolerance for minor sequence variation between species, which is helpful when comparing rodent tissue with patient-derived samples. The glycerol-based buffer keeps the antibody stable through routine freezer handling, but aliquoting on first use reduces freeze-thaw exposure and preserves titre over time.