Anti-DARPP-32 Antibody

Affinity-purified polyclonal reagent raised in rabbit against DARPP-32 (Dopamine- and cAMP-regulated phosphoprotein, 32 kDa), a striatal-enriched phosphatase-1 regulator widely used as a marker of medium spiny neurons in dopaminergic pathway studies. The antibody is supplied unconjugated in a 100 µL vial and supports Western blot detection of the characteristic 32 kDa band, immunofluorescence on tissue sections, and immunohistochemistry workflows on human, mouse, and rat samples. Researchers apply the reagent to characterize dopaminergic signaling activity, examine neuronal plasticity, and verify PPP1R1B expression in neuroscience and neuropharmacology projects. The polyclonal format provides broad epitope coverage of the phosphoprotein, enabling recognition across multiple phosphorylation states that report on cAMP and dopamine cross-talk. Short-term refrigerated storage preserves activity, and aliquoting on first use limits freeze-thaw cycling of the working stock. Antibodies.com manufactures this reagent and confirms cross-species reactivity on each lot against the three listed host organisms, supporting consistent performance across rodent and human sample sets.