Anti-Cytomegalovirus (CMV-ICP8) Antibody

Targeting the CMV-ICP8 single-stranded DNA-binding protein encoded by the UL57 open reading frame, this monoclonal reagent from Antibodies.com enables detection of actively replicating human cytomegalovirus in infected cells. The antibody is a mouse IgG isotype, Protein G purified, and supplied unconjugated at 500 µg per vial for flexibility in assay design.

Recommended applications include western blot (WB) and immunofluorescence assay (IFA), where the antibody recognizes the nuclear accumulation pattern characteristic of lytic-phase CMV infection. Researchers use ICP8 staining alongside immediate-early antigens such as IE1 to distinguish early lytic replication from latent or reactivation events in fibroblast, endothelial, and myeloid culture models.