Anti-Cytokeratin 8 (G427) Antibody

Cytokeratin 8 (KRT8) is a type II intermediate filament protein expressed predominantly in simple epithelia, where it forms obligate heterodimers with Cytokeratin 18. This polyclonal rabbit antibody from Antibodies.com recognizes KRT8 and is supplied as 50 µl of antiserum at 1 mg/ml in phosphate buffered saline (PBS) containing 15 mM sodium azide, approximately pH 7.2.

The unconjugated reagent is applicable to Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF), and shows reactivity with human, mouse, and rat samples. Researchers employ it for epithelial tissue characterization, tumor pathology studies of hepatocellular and glandular carcinomas, and investigations of KRT8 mutations linked to chronic liver disease. The polyclonal format provides multi-epitope recognition of the target, useful when probing denatured, reduced, or fixed specimens in cell culture and tissue-based assays.