Anti-Cytokeratin 8 Antibody

Raised in rabbit, this unconjugated polyclonal reagent targets Cytokeratin 8 (KRT8), a type II keratin intermediate filament protein of approximately 53 kDa that partners with Keratin 18 to build the cytoskeletal scaffold of simple epithelia. The antibody supplied by Antibodies.com is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows, and it cross-reacts with human, mouse, and rat samples, making it useful across comparative epithelial biology studies. Because CK8 is abundantly expressed in hepatocytes, pancreatic acinar and ductal cells, intestinal enterocytes, and simple glandular epithelium, it is widely used as a marker for epithelial differentiation and for identifying carcinoma cells of epithelial origin in tissue sections and cell culture models. Researchers studying liver injury, pancreatic disease, gastrointestinal biology, and epithelial-mesenchymal transition frequently rely on this reagent to confirm lineage, monitor cytoskeletal remodeling, and characterize tumor pathology. The 50 µl vial format suits multiple pilot experiments, and standard handling involves aliquoting on arrival and storing frozen to preserve activity across repeated freeze-thaw cycles.