Anti-Cytokeratin 7 (N-terminus) Antibody

Validated for western blot and immunocytochemistry on human samples, this unconjugated mouse monoclonal primary antibody from Antibodies.com is supplied as 100 µl of purified immunoglobulin in 0.1M Tris-Glycine buffer (pH 7.4) with 150 mM NaCl, 0.2% sodium azide, and 50% glycerol. The reagent targets the N-terminal region of Cytokeratin 7, a type II keratin expressed in a restricted subset of epithelial tissues.

CK7 serves as a widely used tissue marker that helps distinguish epithelial lineages and assists in identifying tumor origin in certain carcinomas. Because the antibody recognizes the N-terminal portion of the protein rather than internal or C-terminal epitopes, it can be used to evaluate full-length CK7 versus caspase-generated cleavage fragments in apoptosis assays, an approach useful in tumor biology and signal transduction research.