Anti-Cytokeratin 2e Antibody

Supplied as 100 µL of unconjugated antiserum in a vial, this rabbit polyclonal reagent from Antibodies.com targets cytokeratin 2e (KRT2), a type II intermediate filament keratin expressed in the upper suprabasal layers of human epidermis and other stratified squamous epithelia. The antibody is validated for Western blot, immunohistochemistry, and immunofluorescence workflows on human samples, supporting studies of terminal keratinocyte differentiation, epithelial barrier formation, and skin barrier biology. Researchers apply the reagent to map keratinization patterns, to characterize differentiation programs in stratified epithelia, and as a marker in dermatopathology research where altered KRT2 expression is associated with conditions such as epidermolytic hyperkeratosis and certain ichthyosis variants. The polyclonal format raises the likelihood of recognizing multiple epitopes on the target, which is useful when probing denatured preparations. The unconjugated format allows secondary-labeling flexibility for chromogenic IHC, fluorescence imaging, and chemiluminescent Western blot detection, with end users choosing secondary reagents matched to their preferred detection chemistry.