Anti-Cytokeratin 18 Antibody

Cytokeratin 18 (KRT18) is a type I intermediate filament protein of approximately 45 kDa that is expressed in simple and glandular epithelia. This unconjugated rabbit polyclonal antibody from Antibodies.com recognizes full-length Cytokeratin 18 in human, mouse, and rat samples, supporting western blot, immunohistochemistry, immunofluorescence, and ELISA workflows. Because Cytokeratin 18 is cleaved by caspases during apoptosis, antibodies against it are commonly used to study epithelial cell death, hepatocyte injury, and circulating epithelial-derived tumor cells. The reagent is supplied in a 100 µl vial of polyclonal antiserum and is suitable for use with cell culture-derived samples, fixed tissue sections, and standard immunoblotting protocols. Researchers working on epithelial biology, carcinoma characterization, or biomarker discovery use Cytokeratin 18 immunoreactivity to distinguish epithelial-derived structures from mesenchymal or lymphoid tissue.