Anti-Cytokeratin 18 Antibody

Raised in rabbit and supplied by Antibodies.com, this unconjugated polyclonal primary antibody targets Cytokeratin 18 (KRT18), a type I intermediate filament protein expressed in simple and glandular epithelial tissues. The reagent is provided as 100 µl of stock solution, validated for western blot, immunohistochemistry, immunoprecipitation, immunofluorescence, and ELISA applications across human, mouse, and rat samples.

Cytokeratin 18 serves as a widely adopted marker for epithelial cells and epithelial-derived carcinomas, supporting research in tumor pathology, tissue architecture, and differentiation studies. Cleaved KRT18 fragments generated by caspase activity are also a recognized indicator of apoptosis, which broadens the antibody's utility into cell-death investigations alongside its role in epithelial characterization and epithelial-mesenchymal transition models.

The unconjugated format gives laboratories flexibility to conjugate the antibody to a preferred label or to use it directly in chromogenic and fluorescent detection workflows. Polyclonal clonality provides broader epitope coverage than a monoclonal reagent, which is particularly valuable when probing post-translationally modified cytokeratin species or partially processed material recovered from fixed tissue archives.