Anti-Cytochrome P450 2D6 Antibody

This rabbit polyclonal primary antibody from Antibodies.com targets human Cytochrome P450 2D6 (CYP2D6), a hepatic phase-I enzyme responsible for the oxidative metabolism of a substantial fraction of clinically used medications, including opioids, antidepressants, antipsychotics, beta-blockers, and the antiestrogen tamoxifen. Supplied as 100 µl of unconjugated antiserum in a single-use vial, the reagent is validated for Western blot and immunohistochemistry workflows on human samples, supporting studies in pharmacogenomics, drug-interaction profiling, and hepatic tissue characterization.

Because CYP2D6 activity is strongly influenced by polymorphic variants that classify patients as poor, intermediate, extensive, or ultrarapid metabolizers, antibody-based detection in liver biopsies and cell lysates complements genotyping when assessing enzyme abundance at the protein level. The polyclonal format recognizes multiple epitopes across the CYP2D6 sequence, which improves signal in immunohistochemistry where accessibility of a single linear epitope may be limited by fixation. For long-term storage, freeze at -20 °C in working aliquots to limit freeze-thaw cycles; protect from light and refrigerate during routine use.

Each lot is affinity-purified and quality-controlled for use in cell biology and liver research laboratories. Research use only — not intended for diagnostic or therapeutic applications.