Anti-CYTH1 Antibody

Antibodies.com offers this unconjugated rabbit polyclonal antibody raised against CYTH1 (Cytohesin-1), a Sec7-family guanine nucleotide exchange factor that activates the ARF1 and ARF6 GTPases at the inner face of the plasma membrane. CYTH1 bridges integrin engagement to actin remodeling and is implicated in leukocyte adhesion, immune synapse organization, and clathrin-independent endocytic trafficking.

Supplied as a 100 µl vial, the reagent has been validated for western blot and immunohistochemistry on human-derived samples. Host species is rabbit, clonality is polyclonal, and the unconjugated format lets investigators couple the primary reagent to their preferred reporter (HRP, biotin, or a fluorophore of choice). The polyclonal response recognizes multiple epitopes on the target protein, which is helpful when probing native tissues where single linear motifs can be masked by post-translational modification.

CYTH1-directed detection is most often deployed in studies of cytoskeletal dynamics, ARF-GEF/ARF-GAP signaling hierarchies, and lymphocyte migration assays. Store refrigerated upon receipt; aliquot the antiserum if extended storage is needed and avoid repeated freeze-thaw cycles to preserve antibody activity. Intended for research use only.