Anti-CYTH1 Antibody

Antibodies.com offers this rabbit polyclonal anti-CYTH1 antibody, a primary antibody raised against Cytohesin-1, a member of the cytohesin family of guanine nucleotide exchange factors (GEFs) that activate ARF GTPases and regulate integrin-mediated adhesion, immune-cell signaling, and cytoskeletal remodeling. The IgG reagent is supplied unconjugated in a 200 µl volume and is validated for western blot detection of endogenous human CYTH1 in cell lysates and tissue extracts.

CYTH1 contains a catalytic Sec7 domain responsible for ARF6 GDP/GTP exchange and a pleckstrin homology domain that docks the protein at phosphatidylinositol-rich membranes of the plasma cortex, so this reagent supports research into membrane trafficking, receptor recycling, and leukocyte adhesion pathways. For best results aliquot upon receipt and store at -20 °C in a manual defrost freezer, protecting the vial from repeated freeze-thaw cycles to preserve activity across multiple blots. Researchers studying ARF6-dependent signaling in human immune cells will find this polyclonal antibody a useful probe for tracking endogenous Cytohesin-1 expression under varying stimulation conditions.