Anti-CyPB Antibody

Cyclophilin B (CyPB) is an endoplasmic reticulum-resident peptidyl-prolyl cis-trans isomerase that catalyzes protein folding and serves as the principal intracellular receptor for the immunosuppressant cyclosporin A. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against CyPB and validated for Western blot and ELISA workflows across Human, Mouse, and Rat samples.

The reagent ships as 100 µl of polyclonal antiserum in a vial, intended for detecting the approximately 21 kDa ER-resident immunophilin in cell lysates, tissue homogenates, and recombinant protein preparations. For optimal stability, store at -20°C in working aliquots to limit freeze-thaw cycles and protect from light during research use only applications.

Investigators commonly deploy this CyPB reagent in studies of collagen biosynthesis and prolyl hydroxylation, endoplasmic reticulum stress and unfolded protein response signaling, HIV-1 and HCV replication mechanisms that exploit host cyclophilins, and cancer cell biology where altered CyPB expression has been reported in solid tumor models. The polyclonal format offers broader epitope coverage than monoclonal alternatives and accommodates detection of both full-length CyPB and processed or modified forms.