Anti-CYP3A7 Antibody

This rabbit polyclonal antibody from Antibodies.com targets human CYP3A7, the predominant cytochrome P450 isoform expressed in fetal liver that accounts for the majority of total hepatic CYP content during prenatal development. CYP3A7 plays a central role in xenobiotic and steroid metabolism in utero and is progressively silenced after birth as CYP3A4 takes over, making this reagent useful for studies of hepatic ontogeny, neonatal drug disposition, and fetal pharmacology. Supplied as 100 µl of unconjugated polyclonal antiserum raised in rabbit, the antibody is validated for western blot and ELISA workflows against human samples and supports investigation into developmental expression patterns, regulation by nuclear receptors such as PXR and CAR, and altered xenobiotic clearance in pediatric populations. Researchers can apply it to characterize CYP3A7 protein levels in hepatic tissue lysates, placental preparations, and relevant cell models, or to distinguish fetal-type from adult-type CYP3A activity in comparative studies.