Anti-CYP3A5 Antibody

CYP3A5 is a member of the cytochrome P450 enzyme family, and this unconjugated polyclonal reagent from Antibodies.com targets the human CYP3A5 protein for detection in research samples. Raised in rabbit as a polyclonal IgG antibody, the reagent is supplied at 200 µl and is validated for western blot, immunohistochemistry, and immunofluorescence workflows. CYP3A5 plays a well-documented role in hepatic and extrahepatic xenobiotic metabolism, making antibodies against it useful in pharmacogenomics studies of drugs such as tacrolimus, midazolam, and several chemotherapeutics whose clearance is influenced by CYP3A5 genotype. The unconjugated format allows laboratories to pair the antibody with their own choice of secondary detection chemistries, including HRP, biotin, or fluorophore conjugates. The reagent is intended for research use only and supports studies of interindividual variation in drug metabolism, tissue-specific CYP3A5 expression, and the contribution of this enzyme to clinically relevant drug-drug interactions in human liver, kidney, and intestinal samples.