Anti-CYP3A5 Antibody

CYP3A5 is a key member of the cytochrome P450 3A subfamily that contributes to the oxidative metabolism of many clinical drugs, including the immunosuppressant tacrolimus and several chemotherapeutic agents, with expression that varies considerably between individuals due to well-characterized genetic polymorphisms. This rabbit polyclonal IgG antibody, supplied by Antibodies.com, is raised against CYP3A5 and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows on human samples, where it can be used to identify individuals who are expressers versus non-expressers of the enzyme. The unconjugated antibody is provided as a 100 µl liquid aliquot and is intended for probing tissue sections and cell preparations to localize CYP3A5 expression in the liver, kidney, and other organs where the enzyme plays a pharmacologically important role. Researchers working in pharmacogenomics, drug metabolism studies, and transplant medicine routinely use anti-CYP3A5 reagents to investigate how CYP3A5 genotype influences tacrolimus dosing requirements and to characterize inter-individual variability in drug clearance.