Anti-CYP3A4 Antibody

CYP3A4 is the dominant cytochrome P450 isoform expressed in human liver and intestinal epithelium, where it catalyzes the oxidative metabolism of roughly half of all clinically used drugs. Accurate detection of CYP3A4 protein is central to pharmacology, toxicology, and drug-drug interaction studies, and this polyclonal antibody from Antibodies.com provides a reagent for immunoblotting and imaging workflows.

The reagent is raised in rabbit, unconjugated, and supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, in a 100 µl vial. It has been validated for Western blot, immunohistochemistry, and immunofluorescence, and reacts with CYP3A4 from human, mouse, and rat samples, enabling cross-species expression profiling and tissue localization in translational research programs.

For handling, the 50% glycerol formulation supports frozen storage in working aliquots to limit freeze-thaw cycles of the antibody stock. Because CYP3A4 expression is highly inducible and polymorphic between individuals, this primary antibody is suited to xenobiotic induction studies, comparative staining of liver and intestinal tissue sections, and confirmatory Western blot analysis of CYP3A4 protein levels across model systems.