Anti-CYP2J2 Antibody

CYP2J2 is a cytochrome P450 monooxygenase widely studied for its role in converting arachidonic acid into epoxyeicosatrienoic acids (EETs), bioactive lipid mediators involved in cardiac electrophysiology, vascular tone regulation, and inflammatory signaling. The enzyme is expressed in heart, liver, kidney, lung, and intestinal epithelia, making it a frequent subject in cardiovascular pharmacology, drug-metabolism, and toxicology research.

This rabbit polyclonal IgG reagent from Antibodies.com is supplied unconjugated at 100 µl per vial, with western blot as its validated application on mouse and rat samples. Polyclonal antibodies recognize multiple epitopes on the CYP2J2 protein, which can be useful when probing expression across tissues or under conditions where post-translational modifications may affect single-epitope binding. Reactivity with species outside the validated mouse and rat panel has not been characterized for this lot, so cross-species work would require additional validation.

Researchers typically apply this antibody to membrane-bound western blot workflows to monitor CYP2J2 protein levels in cardiac microsomes, hepatic lysates, or renal tissue homogenates from rodent disease or drug-treatment models. It is also useful in studies of xenobiotic-metabolizing enzymes where CYP2J2 regulation is being compared alongside other P450 family members in the same blot.

For handling, refrigerate the vial on receipt and protect from light; if it will be used over an extended period, aliquot to limit repeated freeze-thaw cycles and preserve binding activity. Intended for research use only.