Anti-CYP2E1 Antibody

CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) is a phase I drug-metabolizing enzyme expressed predominantly in liver hepatocytes, where it oxidizes a broad substrate spectrum that includes ethanol, acetaminophen, and several small xenobiotics. This rabbit polyclonal antibody from Antibodies.com is raised against CYP2E1 and supplied as an unconjugated reagent in a 50 µl vial, suitable for western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

The polyclonal format provides recognition of multiple epitopes on the CYP2E1 protein, supporting detection in tissue sections and cell-based imaging. For western blot, the antibody is commonly used on liver-derived lysates, where the enzyme is most abundant, and is also applied in studies of hepatic injury, alcohol metabolism, and drug-induced oxidative stress. Recommended storage is at -20 °C in working aliquots to limit freeze-thaw cycles, with brief handling on ice during use.

Researchers investigating hepatic CYP induction, toxicology, or the metabolic activation of carcinogens can pair this reagent with appropriate secondary antibodies for chromogenic or fluorescence imaging. Each lot is quality-controlled for the stated applications, and the unconjugated format allows flexibility in choosing HRP, biotin, or fluorophore conjugates during secondary staining setup.