Anti-CYP2D6 (R450) Antibody

CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6) is a hepatic monooxygenase that metabolizes roughly a quarter of all clinically prescribed drugs, including many antidepressants, opioids, beta-blockers, and antipsychotics. Polyclonal antibodies raised against this enzyme support pharmacogenomics and toxicology research, helping laboratories characterize hepatic expression, profile individual metabolic phenotypes, and investigate drug-drug interactions at the protein level.

This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, and is packaged as a 50 µl vial. The antibody is validated for Western blot (WB) and immunohistochemistry (IHC) applications and has been confirmed to react with Human, Mouse, and Rat samples, enabling translational studies across rodent disease models and human tissue specimens.

CYP2D6 expression is highly polymorphic, and differences in protein levels contribute to poor, intermediate, extensive, and ultrarapid metabolizer phenotypes. Researchers investigating adverse drug reactions, codeine and tramadol activation, tamoxifen efficacy, and antidepressant clearance rely on this marker to stratify samples. The polyclonal format offers broad epitope recognition, useful when probing denatured targets on membranes or formalin-fixed paraffin-embedded sections where epitope masking can otherwise limit detection.