Anti-CYP2D6 Antibody

Antibodies.com provides a rabbit polyclonal antibody targeting Cytochrome P450 2D6, an enzyme central to hepatic drug metabolism and pharmacogenomic research. CYP2D6 catalyzes the oxidative biotransformation of a substantial fraction of clinically prescribed medications, including antidepressants, antipsychotics, beta blockers, and opioids such as codeine, making dependable immunological detection valuable for both basic biochemistry and translational pharmacology studies.

The reagent is supplied as a 200 µL liquid vial of unconjugated IgG, validated for Western blot analysis of tissue lysates and for immunohistochemistry on formalin-fixed paraffin-embedded sections. Cross-reactivity has been verified across Human, Mouse, and Rat samples, facilitating comparative work between rodent disease models and human hepatic phenotypes. As a polyclonal reagent, the antibody recognizes multiple epitopes along the CYP2D6 sequence, which can improve signal recovery when target abundance is low or when working with partially degraded preparations.

For immunoblotting, the antibody can be applied to denatured protein extracts separated by SDS-PAGE, while tissue section staining is performed on formalin-fixed paraffin-embedded material using standard antigen retrieval workflows. Refrigerate the vial upon arrival, protect from light, and aliquot to minimize freeze-thaw cycles and preserve binding activity over the working shelf life.