Anti-CYP2D6 (A300) Antibody

This rabbit polyclonal primary antibody targets cytochrome P450 2D6 (CYP2D6), a phase I drug-metabolizing enzyme best known for its role in the oxidative metabolism of roughly a quarter of clinically prescribed medications, including opioids, antidepressants, beta-blockers, and antipsychotics. Antibodies.com supplies it as a 100 µL liquid aliquot at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide, at approximately pH 7.2. The unconjugated antibody is raised in rabbit and is suitable for western blot and immunohistochemistry workflows. It cross-reacts with mouse and rat tissue in addition to the human target, which is helpful for translational studies that pair human specimens with rodent disease models. CYP2D6 is a highly polymorphic hepatic protein, and the reagent can be used to assess relative expression across genotypes in tissue sections and cell lysates. Refrigerate on receipt and avoid repeated freeze-thaw cycles to preserve antigen-binding activity.