Anti-CYP2B6 Antibody

CYP2B6 is a Phase I drug-metabolizing cytochrome P450 enzyme anchored to the endoplasmic reticulum of hepatocytes, where it oxidizes a clinically important share of prescribed medications including bupropion, efavirenz, ketamine, and cyclophosphamide. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com selectively detects CYP2B6 in human, mouse, and rat samples by Western blot and immunohistochemistry, supporting studies of xenobiotic metabolism, hepatic physiology, and pharmacogenomic variation in drug clearance.

The antibody is supplied as 50 µl of polyclonal serum, unconjugated and ready for downstream labeling or direct use in standard chromogenic and chemiluminescent detection workflows. Researchers investigating interindividual variability in CYP2B6 expression, isoform-specific induction by xenobiotics, or hepatic zonation patterns can apply this reagent to fixed tissue sections and denatured protein lysates. To preserve antibody activity across repeated experiments, users typically aliquot on arrival and keep aliquots frozen, protecting the reagent from light and limiting freeze-thaw cycles.