Anti-CYP2B6 Antibody

CYP2B6 belongs to the cytochrome P450 superfamily of monooxygenase enzymes, where it contributes to phase I metabolism of a substantial share of clinically prescribed drugs, including bupropion, efavirenz, cyclophosphamide and methadone. This rabbit polyclonal IgG reagent from Antibodies.com was raised against CYP2B6 and is supplied as an unconjugated 200 µl aliquot suitable for Western blot and immunohistochemistry workflows.

The antibody has been validated for reactivity against human, mouse and rat samples, supporting hepatic tissue studies, pharmacogenomics research and investigations of xenobiotic-metabolizing capacity. Researchers apply it to characterize CYP2B6 expression in liver microsomes, tumor biopsies and rodent models of drug-induced liver injury, where its polyclonal nature provides broader epitope coverage than monoclonal alternatives and aids detection across multiple species. Because CYP2B6 is highly inducible by compounds such as rifampicin and phenobarbital, the reagent is also useful for tracking transcriptional responses in cultured hepatocytes and for studying inter-individual variability in drug clearance.