Anti-CYP2A6V2 Antibody

Affinity-purified polyclonal antiserum raised in rabbit against the CYP2A6V2 variant of human cytochrome P450 2A6, a hepatic enzyme central to the oxidative metabolism of nicotine, coumarin, and several clinically administered drugs. This unconjugated Primary Antibody from Antibodies.com is supplied as 100 µl of ready-to-use reagent and is validated for Western blot, immunohistochemistry, and ELISA workflows using human-derived samples.

The immunogen targets a sequence region of CYP2A6V2 that distinguishes this isoform from full-length CYP2A6, allowing researchers to discriminate the variant in tissue lysates and fixed sections. Its polyclonal nature supports detection of low-abundance targets where signal amplification is helpful, and the unconjugated format lets end-users couple it to their preferred reporter or bead system.

Typical laboratory uses include probing expression of CYP2A6V2 in liver microsomal preparations, characterizing variant-specific metabolism in pharmacogenomic studies, and localizing the isoform by immunohistochemistry in hepatic and extrahepatic tissue. For handling, refrigerate the vial upon arrival, aliquot to working volumes, and avoid repeated freeze-thaw cycles to preserve antibody activity across long-term studies.