Anti-CYP2A6 Antibody

Raised in rabbit and supplied as an unconjugated polyclonal reagent in a 100 µl vial, this Antibodies.com antibody targets human cytochrome P450 2A6, the hepatic enzyme that drives coumarin 7-hydroxylation and the C-oxidation of nicotine to cotinine. Validation covers western blot and immunohistochemistry workflows, with reactivity reported on human tissue where the isoform is most abundantly expressed. The unconjugated format leaves secondary antibody choice, custom labelling, and signal amplification fully in the researcher's hands.

CYP2A6 sits at the centre of hepatic xenobiotic metabolism, so laboratories working on drug clearance, nicotine disposition, or pharmacogenomic variation commonly deploy this reagent to probe protein abundance in lysates and fixed sections. Affinity detection on paraffin-embedded or frozen liver tissue is supported, and the polyclonal IgG backbone tolerates minor sequence variation while still recognising the full-length protein after SDS-PAGE separation. Host rabbit immunoglobulins enable flexible pairing with common anti-rabbit secondaries for chromogenic or fluorescent readouts on both western blot membranes and IHC slides.